Research News
 
 
February 12, 2019
 
 
RESEARCH EVENTS & SEMINARS

New Community Engagement Initiative
Keck School of Medicine Pre-grant review program
Lunch & Discuss with Biostatistics Experts
2019 TSRI Annual Symposium: "Big Data - Big Impact", February 12
Role of the Neural Niche in Brain Metastasis, February 12
Pilot Funding Programs at the Keck School, February 13
Interrogating the relationship between liver injury, regeneration, and cancer., February 14
New Insights into the Pathogenesis of Alpha-1-Antitrypsin Deficiency Lung and Liver Disease, February 15
"The Great Decline in Adolescent Smoking: Consequences for Illegal Drug Use.", February 15
Synergies Between Vocal Production and Auditory Perception in Voice Masculinization Therapy for Gender Diverse Patients, February 19
Signaling Pathways that Lead to Innitiation and Progression of Hepatocellular Carcinoma, February 21
Hastings Center for Pulmonary Research Annual Retreat 2019, February 22
Research Seminar: "Tight Glycemic Control in Critically Ill Children: BitterSweet", February 22
Data Sharing in Clinical Trials, February 26
USC's 6th Annual Research Symposium on Diabetes and Obesity, February 26
"Effect of ATP-Adenosine metabolism and function in autoimmune responses.", February 26
USC's 6th Annual Research Symposium on Diabetes and Obesity, February 27
Dissecting Lipotoxic and Proteotoxic Stress in Normal and Disease States, February 28
CDSS-Preparing for an Associate Professor Appointment, February 28
Hastings Center for Pulmonary Research Seminar Series, March 1
Difficult Discussions: Tips from an Expert, March 5
Research Seminar: "Early Life Stress: Impact on Neural Circuits Related to Affective State and Drug Reward", March 6
Digital Scholar Webinar: Social Media and the 21st-Century Scholar: How Researchers Can Harness Social Media to Amplify Their Career, March 6
Inhibition of sodium-glucose cotransport in the diabetic kidney, March 7
Statistical analysis: What statistical methods are appropriate for my study design and data collection, March 11
Hastings Center for Pulmonary Research Seminar Series, March 15
Hepatic insulin resistance dysregulates Fox)-regulated hepatokines that promote systemic metabolic disease, March 21
RNA modification in cancer: Function, mechanism and therapeutic implications, March 28
Hastings Center for Pulmonary Research Seminar Series, March 29
Autophagy: connecting quality control & metabolic functions, April 4
Hastings Center for Pulmonary Research Seminar Series, April 5
Hastings Center for Pulmonary Research Seminar Series, April 19
Hastings Center for Pulmonary Research Seminar Series, May 10


 
 
New Community Engagement Initiative

USC Keck School of Medicine has a new Community Engagement initiative to "hear, learn, understand and fulfill the needs of the community".

Website    
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Keck School of Medicine Pre-grant review program

The Keck School of Medicine supports high-quality pre-reviews of external grant applications from new investigators applying for their first NIH R001, R21, K99/R00 or comparable federal research grant. Reviews will address 1) general grantsmanship including the effectiveness of presentation, flow, and quality of supporting documentation and 2) scientific content. Scientific experts participating in the review process will receive honoraria. We strongly encourage investigators to take advantage of this pre-grant review program.

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Lunch & Discuss with Biostatistics Experts

Who should attend? Investigators who are thinking about developing a research grant proposals.

When are the meetings? Every third Monday of each month.

Be sure to bring your draft specific aims to the session.

Lunch is first to come first served.

Feel free to join the SC CTSI Biostatisics Discussion Board on LinkedIn (see the link below).

Flyer  LinkedIn Biostatistics Discussion Group  
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EVENT DETAILS

Tuesday, February 12
2019 TSRI Annual Symposium: "Big Data - Big Impact"
The Saban Research Institute of Children's Hospital Los Angeles Annual Symposium

8:00 AM-5:00 PM

Auditorium, The Saban Research Institute of Children's Hospital Los Angeles, 4661 Sunset Blvd., Los

The Saban Research Institute Annual Symposium highlights exciting strides being made by researchers from Children's Hospital Los Angeles, the University of Southern California (USC) and around the globe in understanding the developmental origins of health and disease. Each year, the theme of the symposium reflects a research priority area of The Saban Research Institute and USC.

Website  Full Details
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Tuesday, February 12
Role of the Neural Niche in Brain Metastasis
Cancer Center Grand Rounds

12:00 PM-1:00 PM

Aresty Auditorium

Josh Neman, PhD Assistant Professor of Neurosurgery Keck School of Medicine

Details  Full Details
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Wednesday, February 13
Pilot Funding Programs at the Keck School
Pilot Funding Programs at the Keck School Learn about the Programs... hear from the awardees!

1:30 PM-6:30 PM

NRT LG503/4 - Harlyne Tower

Pilot Funding Program at the Keck School Event and the Reviewer Appreciation Reception

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Thursday, February 14
Interrogating the relationship between liver injury, regeneration, and cancer.
Cellular Homeostasis Lecture Series

12:00 PM-1:00 PM

McKibben (MCH) Lecture Hall Room 156 - 1333 San Pablo Street, Los Angeles, CA 90033

Hao Zhu, M.D.
UT Southwestern Medical Center

Dr. Zhu's lab seeks to determine if the ability to regenerate and repair lost tissues increases or decreases the risk of cancer. Although it is often assumed that increased regenerative capacity confers greater cancer risk, Dr. Zhu hypothesizes that the potent regenerative abilities of the skin, intestine, and liver could serve to preserve tissue integrity, reduce inflammation, and resist transformation in the context of recurrent injury. With this in mind, the lab has identified genetic pathways that augment regenerative capacity in mammals while simultaneously reducing cancer risk. Dr. Zhu's lab has also discovered that hepatocyte polyploidization potently suppresses cancer development without compromising regenerative capacity. These basic investigations are brought to bear on the problem of hepatocellular carcinoma, which most frequently arises in chronically damaged livers. Dr. Zhu is a physician-scientist and associate professor at UT Southwestern. He received his M.D. from Harvard Medical School and Massachusetts Institute of Technology. He completed his postdoctoral training at Harvard Medical School, Boston Children's Hospital

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Friday, February 15
New Insights into the Pathogenesis of Alpha-1-Antitrypsin Deficiency Lung and Liver Disease
Hastings Center for Pulmonary Research Seminar Series

8:30 AM-9:30 AM

Hastings Auditorium (HMR 100)

Mark Brantly, MD
Professor of Medicine
Vice Chair of Research, Department of Medicine
Alpha-1 Foundation Research Professor
University of Florida College of Medicine

Full Details
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Friday, February 15
"The Great Decline in Adolescent Smoking: Consequences for Illegal Drug Use."
USC Institute for Addiction Science Speaker Series - Richard Miech

1:30 PM-3:00 PM

SSB 117

Richard Miech, Ph.D., is the Principal Investigator of the Monitoring the Future Survey, a nationally-representative survey that annually surveys about 45,000 adolescents in ~400 schools throughout the U.S. He is a Research Professor at the University of Michigan's Institute for Social Research. He received his Ph.D. degree in Sociology from the University of North Carolina at Chapel Hill and a MPH degree from Johns Hopkins University. His work focuses on trends in substance use, with an emphasis on disentangling how these trends vary by age, historical period, and birth cohort membership. Other research interests include the rapid growth of vaping in recent years and its long-term consequences. Dr. Miech's presentation focuses on the "great decline" in adolescent cigarette smoking, which has led to a fourfold decline in the past two decades. This decline would be expected to carry with it a decrease in levels of adolescent use of illegal drugs, including marijuana, binge drinking, opioids, amphetamines, and tranquilizers. In this paper he considers the degree to which the decline in smoking has brought about declines in use of these other drugs, and projects what adolescent use of these drugs would look like today if the great decline in adolescent cigarette smoking had not taken place.

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Tuesday, February 19
Synergies Between Vocal Production and Auditory Perception in Voice Masculinization Therapy for Gender Diverse Patients
Otolaryngology and Hearing & Communication Neuroscience Seminar Series

4:00 PM-5:00 PM

USC Health Science Campus Broad Auditorium

This presentation discusses synergies between vocal production and auditory perception of vocal gender in voice masculinization therapy.

Details  Full Details
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Thursday, February 21
Signaling Pathways that Lead to Innitiation and Progression of Hepatocellular Carcinoma
Cellular Homeostasis Lecture Series

12:00 PM-1:00 PM

McKibben (MCH) Lecture Hall Room 156 - 1333 San Pablo Street, Los Angeles, CA 90033

Debanjan Dhar, Ph. D.
Assistant Professor
University of California, San Diego


Details  More Details  Full Details
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Friday, February 22
Hastings Center for Pulmonary Research Annual Retreat 2019
8:00 AM-4:00 PM

Huntington Library Board Room

"Stem cells as targets and therapies for cystic fibrosis and other lung diseases"
Scott H. Randell, PhD
Associate Professor
Cell Biology and Physiology
Marisco Lung Institute
University of North Carolina

To RSVP or for additional information please contact Mary Jane Chua at hcpr@med.usc.edu.

Schedule  
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Friday, February 22
Research Seminar: "Tight Glycemic Control in Critically Ill Children: BitterSweet"
The Saban Research Institute of Children's Hospital Los Angeles Wednesday Seminar Series

12:00 PM-1:00 PM

Auditorium, The Saban Research Institute of Children's Hospital Los Angeles, 4661 Sunset Blvd., Los

Presented by Vijay Srinivasan, MBBS, MD, FCCM Assistant Professor of Anesthesiology, Critical Care and Pediatrics Perelman School of Medicine at the University of Pennsylvania Attending Physician, Department of Anesthesiology and Critical Care Medicine The Children's Hospital of Philadelphia Wednesday, February 20, 2019 12-1 p.m. The Saban Research Building Auditorium 4661 Sunset Blvd., Los Angeles, CA 90027

Details  Full Details
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Tuesday, February 26
Data Sharing in Clinical Trials
Department of Medicine Grand Rounds

12:00 PM-1:00 PM

Hastings Auditorium (HMR 100)

Jeffrey M. Drazen, MD
Editor-in-Chief, New England Journal of Medicine
Distinguished Parker B. Francis Professor of Medicine, Harvard Medical School
Professor of Physiology, Harvard T.H. Chan School of Public Health

- Learn how clinical trial data have and have not been shared and the consequences thereof.
- Learn the imperatives for and barriers to clinical trial data sharing
- Learn the recommendations for sharing data set forth by the International Committee of Medical
Journal Editors

Flyer  Full Details
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Tuesday, February 26
USC's 6th Annual Research Symposium on Diabetes and Obesity
DORI's Annual Symposium - Day 1

1:00 PM-7:00 PM

Aresty & NRT, LG 503/504

No cost 2-day symposium on diabetes and obesity. Day 1 details.

Details  More Details  Full Details
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Tuesday, February 26
"Effect of ATP-Adenosine metabolism and function in autoimmune responses."
Distinguished Ophthalmology (Research) Lecture Series

5:00 PM-6:00 PM

HC4-3rd floor, conference room

Distinguished Ophthalmology (Research) Lecture Series, "Effect of ATP-Adenosine Metabolism and Function in Autoimmune Responses" Presented by: Deming Sun, MD

Details  Full Details
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Wednesday, February 27
USC's 6th Annual Research Symposium on Diabetes and Obesity
DORI's Annual Symposium - Day 2

8:30 AM-7:00 PM

Aresty & NRT, LG 503/504

No cost 2-day symposium on diabetes and obesity. Day 2 details.

Details  More Details  Full Details
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Thursday, February 28
Dissecting Lipotoxic and Proteotoxic Stress in Normal and Disease States
Cellular Homeostasis Lecture Series

12:00 PM-1:00 PM

McKibben (MCH) Lecture Hall Room 156 - 1333 San Pablo Street, Los Angeles, CA 90033

Maho Niwa Rosen, PhD
Professor, Division of Biological Science
University of California, San Diego

Details  More Details  Full Details
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Thursday, February 28
CDSS-Preparing for an Associate Professor Appointment
Preparing for an Associate Professor Appointment

3:00 PM-5:00 PM

Harkness Auditorium CSC250 - 2250 Alcazar, Los Angeles 90033

This seminar covers USC promotion policies, a Department Chair's perspective on guiding faculty towards successful promotion, a framework on how to prepare for and understand the promotion process.

Details  More Details  Full Details
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Friday, March 1
Hastings Center for Pulmonary Research Seminar Series
8:30 AM-9:30 AM

IRD 734

Steve Dudek, MD
Division Chief, Pulmonary Critical Care, Sleep and Allergy
Professor of Medicine, Pulmonary
University of Illinois at Chicago

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Tuesday, March 5
Difficult Discussions: Tips from an Expert
SC CTSI and MESH Academy event

12:00 PM-1:00 PM

NRT LG 503/504

Join us for the second of our "Difficult Discussions" series. Dr. Brinell Anderson will provide practical tips on approaching difficult discussions.

Details  More Details  Full Details
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Wednesday, March 6
Research Seminar: "Early Life Stress: Impact on Neural Circuits Related to Affective State and Drug Reward"
The Saban Research Institute of Children's Hospital Los Angeles Wednesday Seminar Series

12:00 PM-1:00 PM

Auditorium, The Saban Research Institute of Children's Hospital Los Angeles, 4661 Sunset Blvd., Los

Presented by Elena Chartoff, PhD Associate Professor, Psychiatry & Neuroscience Harvard Medical School Director, Neurobiology of Motivated Behavior Laboratory Director, Education & Training, Basic Neuroscience Division, McLean Hospital Wednesday, March 6, 2019 12-1 p.m. The Saban Research Building Auditorium 4661 Sunset Blvd., Los Angeles, CA 90027

Details  More Details  Full Details
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Wednesday, March 6
Digital Scholar Webinar: Social Media and the 21st-Century Scholar: How Researchers Can Harness Social Media to Amplify Their Career
Digital Scholar Webinar Series

12:00 PM-1:00 PM

Online Webinar

This webinar will highlight successful case studies that show how scientists and scholars might use social media to enhance their careers and outline five key steps scientists can follow to build and manage your scholarly presence online.

Details  Full Details
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Thursday, March 7
Inhibition of sodium-glucose cotransport in the diabetic kidney
Cellular Homeostasis Lecture Series

12:00 PM-1:00 PM

McKibben (MCH) Lecture Hall Room 156 - 1333 San Pablo Street, Los Angeles, CA 90033

Dr. Vallon is a Professor of Medicine in Pharmacology at the University of California San Diego. He received his M.D. from the University of Tübingen (Germany), and research training at the University of Tübingen, UC San Diego, and the National Institutes of Health (Bethesda). His seminar will discuss the unexpected logic and pleiotropic effects of SGLT2 inhibition in the diabetic kidney, which may contribute to protective effects on the kidney and heart.

Most capacity for renal glucose reabsorption is provided by the sodium glucose cotransporter SGLT2 in the early proximal tubule. SGLT2 inhibtors induce glucosuria and thereby improve glycemic control in diabetes. The risk of SGLT2 inhibitors to cause hypoglycemia is low because they stop working when the filtered glucose load falls below the capacity of SGLT1, expressed in the late proximal tubule, and they don't interfere with metabolic counter-regulation. Because SGLT2 reabsorbs glucose together with Na+ and potentially interacts with the Na+/H+-exchanger NHE3 and the urate transporter URAT1 in the proximaltubule, SGLT2 inhibitors are natriuretic, uricosuric and antihypertensive. SGLT2 inhibitors increase delivery of fluid and electrolytes to the macula densa, thereby activating tubuloglomerular feedback and increasing tubular back pressure, which mitigates glomerular hyperfiltration, reduces the kidney's demand for oxygen, and lessens albuminuria.

Details  More Details  
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Monday, March 11
Statistical analysis: What statistical methods are appropriate for my study design and data collection
Lunch and Learn: Biostatistics SC CTSI 4-Part Series Part 4

11:30 AM-1:30 PM

NRT LG503/4 - Harlyne Tower

Currently open to all faculty. A version of these workshops may be offered to staff and students at a later time.

Workshops recommended to be taken in sequence.

Stand alone registration is OK.


Details  Full Details
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Friday, March 15
Hastings Center for Pulmonary Research Seminar Series
8:30 AM-9:30 AM

Hastings Auditorium (HMR 100)

Ross Summer, MD
Professor of Medicine
Sidney Kimmel Medical College
Philadelphia University + Thomas Jefferson University

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Thursday, March 21
Hepatic insulin resistance dysregulates Fox)-regulated hepatokines that promote systemic metabolic disease
Cellular Homeostasis Lecture Series

12:00 PM-1:00 PM

McKibben (MCH) Lecture Hall Room 156 - 1333 San Pablo Street, Los Angeles, CA 90033

Morris Francis White, PhD
Boston Children's Hospital

Dr. White's is a prominent investigator who specializes in the investigation of insulin signaling and its importance in human diseases. One of his research focuses is to determine the criticalness of insulin signaling and insulin resistance in the context of fatty liver disease with the ultimate goal to establish a novel therapeutic and prevention strategies of this rapidly growing disease entity.

Insulin signaling is mediated through the insulin receptor substrate proteins IRS1 and IRS2. In the liver, IRS pathways regulate gene expression and metabolism via suppression of a transcription factor, namely FoxO1. His laboratory discovered that hepatic FoxO1 has great in?uence on the development of insulin resistance not only in the liver but also in peripheral organs. The insulin resistance is the prerequisite for the development of fatty liver disease.

Accordingly, this seminar will discuss the criticalness of IRS in insulin signaling and insulin resistance of hepatocytes. In addition, this seminar will highlight the importance of metabolic cross-talk governed by the insulin signaling in the development of NAFLD.

Dr. White is a professor at Boston Children's Hospital. He received his Ph.D. degree from the University of Michigan, Ann Arbor. He completed his postdoctoral training at the University of Michigan as well as at Harvard Medical School.

Details  More Details  
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Thursday, March 28
RNA modification in cancer: Function, mechanism and therapeutic implications
Cellular Homeostasis Lecture Series

12:00 PM-1:00 PM

McKibben (MCH) Lecture Hall Room 156 - 1333 San Pablo Street, Los Angeles, CA 90033

Jianjun Chen, PhD
Professor and Chair in Systems Biology
Beckman Research Institute of City of Hope

Seminar is open to all faculty, staff and students.

Some internal adenosine residues are methylated in mammalian mRNA. The N-6 methyladenosine (m6A) modi?cation is regulated by methyltransferases (writers), demethylases (erasers), and binding proteins (readers). Dr. Chen's group identi?ed that m6A demethylation enhances oncogene-mediated transformation in acute myeloid leukemia. They showed that the m6A methyltransferase complex regulates self-renewal and differentiation of hematopoietic stem cells. Their recent study also identi?ed that insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) bind to m6A and enhance mRNA stability and translation. In his seminar, he will talk about recent advances in the study of molecular mechanisms of dysregulated m6A modi?cation in cancers and discuss possible therapeutic interventions against the dysregulated m6A machinery to treat cancers.

Part of Pathology 575: Frontiers of Pathology

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Friday, March 29
Hastings Center for Pulmonary Research Seminar Series
8:30 AM-9:30 AM

Hastings Auditorium (HMR 100)

Melanie Königshoff, MD, PhD
Professor of Pulmonary Sciences and Critical Care Medicine
University of Colorado Denver

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Thursday, April 4
Autophagy: connecting quality control & metabolic functions
Cellular Homeostasis Lecture Series

12:00 PM-1:00 PM

McKibben (MCH) Lecture Hall Room 156 - 1333 San Pablo Street, Los Angeles, CA 90033

Vojo Deretic, Ph.D.
Professor
University of New Mexico



Details  More Details  Full Details
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Friday, April 5
Hastings Center for Pulmonary Research Seminar Series
8:30 AM-9:30 AM

IRD 734

Xingbin Ai, PhD
Adjunct Assistant Professor of Medicine
Division of Pulmonary, Allergy, Sleep & Critical Care
Boston University School of Medicine

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Friday, April 19
Hastings Center for Pulmonary Research Seminar Series
8:30 AM-9:30 AM

Hastings Auditorium (HMR 100)

Bethany Moore, PhD, ATSF
Galen B. Towes, M.D. Professor of Internal Medicine
Professor of Microbiology and Immunology
University of Michigan

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Friday, May 10
Hastings Center for Pulmonary Research Seminar Series
8:30 AM-9:30 AM

TBA

Brian R. Davis, PhD
Director, Center for Stem Cell & Regenerative Medicine
C. Harold and Lorine G. Wallace Distinguished University Chair
University of Texas Health Science Center at Houston

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